Resource Type

Journal Article 424

Conference Videos 1

Year

2023 50

2022 52

2021 44

2020 41

2019 29

2018 21

2017 28

2016 14

2015 18

2014 19

2013 7

2012 15

2011 8

2010 9

2009 13

2008 9

2007 17

2006 10

2005 3

2004 4

open ︾

Keywords

identification 9

COVID-19 5

damage identification 5

2019-nCoV 3

B-spline 2

Bayesian inference 2

Inverse problem 2

Programmable 2

System identification 2

acceleration 2

acute myeloid leukemia 2

additive 2

compressive strength 2

diagnosis 2

different 2

implementation 2

mutations 2

nanofiltration 2

organogelator 2

open ︾

Search scope:

排序： Display mode:

Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Frontiers of Medicine   Pages 1006-1009 doi: 10.1007/s11684-023-1000-3

Abstract: Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Keywords： family craniofacial microsomia     Identification novel mutations    

HTML PDF Collect

Mechanical design, modeling, and identification for a novel antagonistic variable stiffness dexterous

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 3, doi: 10.1007/s11465-022-0691-5

Abstract: This study traces the development of dexterous hand research and proposes a novel antagonistic variableExperimental results of the finger joint stiffness identification and finger impact tests under different

Keywords： multifingered hand     mechanism design     robot safety     variable stiffness actuator    

HTML PDF Collect

Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular

Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 419-429 doi: 10.1007/s11684-010-0160-0

Abstract: The association of viral mutations and haplotypic carriages with mutations in the preS region of hepatitis, and G3191C were significantly associated with increased risks of HCC in genotype C, whereas these mutationsMultivariate regression analyses showed that C76A/T was a novel factor independently associated withConclusively, the association of HBV mutations in the preS region with HCC depends on HBV genotype andhaplotypic carriage with two or more mutations that are each associated with an increased risk of HCC

Keywords： hepatitis B virus     hepatocellular carcinoma     mutation     genotype     haplotype    

HTML PDF Collect

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 18-42 doi: 10.1007/s11684-022-0976-4

Abstract: With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expandingTherefore, this review aimed to classify the management of NSCLC with driver mutations based on the geneThirdly, we discuss the effectiveness of ICIs for NSCLC with driver mutations and the combined therapeutictreatment strategies for the new oncogenic alternations, and proposed the perspective of NSCLC with driver mutationsThis review will guide clinicians to design tailored treatments for NSCLC with driver mutations.

Keywords： non-small cell lung cancer     driver mutations     treatment strategy     resistant mechanism     immune-checkpoint    

HTML PDF Collect

Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 112-121 doi: 10.1007/s11684-012-0199-1

Abstract: These findings lead to the development of novel compounds targeting CSC populations that is becoming

Keywords： cancer stem cell     tumor model     drug discovery    

HTML PDF Collect

Characteristics of compensatory mutations in the

Shengfen Wang, Yang Zhou, Bing Zhao, Xichao Ou, Hui Xia, Yang Zheng, Yuanyuan Song, Qian Cheng, Xinyang Wang, Yanlin Zhao

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 51-59 doi: 10.1007/s11684-019-0720-x

Abstract: with mutations and the relation between mutations and tuberculosis (TB) transmission.Twenty-nine nonsynonymous single mutations and three double mutations were identified.The mutations at locus 483 (11.3%) were predominant, and the mutations at V483G, W484G, I491V, L516PFifteen new mutations in the gene were identified.Rifampin resistance and mutations at locus 531 were significantly associated with mutations.

Keywords： tuberculosis     drug resistance     compensatory mutations     transmission    

HTML PDF Collect

122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract: the IL-1A gene and its multiplicative interactions with hepatitis B virus (HBV) mutationsHBV mutations were determined by direct sequencing.Multivariate logistic regression analyses were performed to test the associations of rs3783553, mutations

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (HBV) mutations    

HTML PDF Collect

Conceptual design and kinematic analysis of a novel parallel robot for high-speed pick-and-place operations

Qizhi MENG, Fugui XIE, Xin-Jun LIU

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 2,   Pages 211-224 doi: 10.1007/s11465-018-0471-4

Abstract:

This paper deals with the conceptual design, kinematic analysis and workspace identification of anovel four degrees-of-freedom (DOFs) high-speed spatial parallel robot for pick-and-place operations.

Keywords： spatial parallel robot     pick-and-place operations     mobility analysis     kinematic modeling     workspace identification    

HTML PDF Collect

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Its dysfunction, caused by either fusions or mutations, is frequently reported in acute myeloid leukemiaHowever, RUNX1 mutations have been largely under-explored compared with RUNX1 fusions mainlybased on 1741 patients with AML, we report a unique expression pattern associated with RUNX1 mutationswere mainly distributed in the Runt domain and almost mutually exclusive with NPM1 mutations.This study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

HTML PDF Collect

Variational mode decomposition based modal parameter identification in civil engineering

Mingjie ZHANG, Fuyou XU

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 5,   Pages 1082-1094 doi: 10.1007/s11709-019-0537-3

Abstract: An out-put only modal parameter identification method based on variational mode decomposition (VMD) isA novel procedure is developed to calculate the instantaneous modal frequencies and instantaneous modalThe proposed identification method can straightforwardly extract the mode shape vectors using the modaldemonstrate the efficiency and highlight the superiority of the proposed method in modal parameter identificationThe proposed method is proved to be efficient and accurate in modal parameter identification for both

Keywords： modal parameter identification     variational mode decomposition     civil structure     nonlinear system     closely    

HTML PDF Collect

Genomic Mutations within the Host Microbiome: Adaptive Evolution or Purifying Selection Review

Jiachao Zhang,Rob Knight,

Engineering 2023, Volume 20, Issue 1,   Pages 96-102 doi: 10.1016/j.eng.2021.11.018

Abstract: More human microbiome research projects—particularly those that explore genomic mutations withinWe also explore the correlation between microbial genomic mutations and common metabolic diseases, andFinally, we discuss advances in methods and algorithms for annotating and analyzing microbial genomic mutations

Keywords： Gut microbiota     Genomic mutations     Adaptive evolution     Purifying selection     Single-nucleotide variants    

HTML PDF Collect

Non-convex sparse optimization-based impact force identification with limited vibration measurements

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 3, doi: 10.1007/s11465-023-0762-2

Abstract: Impact force identification is important for structure health monitoring especially in applications involvingDifferent from the traditional direct measurement method, the impact force identification technique is> regularization often identifies false forces in non-loaded regions, interfering with the accurate identificationTo alleviate such limitations, a novel non-convex sparse regularization method that uses the non-convexSimulations and experiments are performed on a composite plate to verify the identification accuracy

Keywords： impact force identification     inverse problem     sparse regularization     under-determined condition     alternating    

HTML PDF Collect

The research on structural damage identification using rough set and integrated neural network

Juelong LI, Hairui LI, Jianchun XING, Qiliang YANG

Frontiers of Mechanical Engineering 2013, Volume 8, Issue 3,   Pages 305-310 doi: 10.1007/s11465-013-0259-5

Abstract:

A huge amount of information and identification accuracy in large civil engineering structural damageidentification has not been addressed yet.To efficiently solve this problem, a new damage identification method based on rough set and integratedThe decision fusion network will give the final damage identification results.The identification examples show that this method can simplify the redundant information to reduce the

Keywords： rough set     integrated neural network     damage identification     decision making fusion    

HTML PDF Collect

Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 356-362 doi: 10.1007/s11684-010-0220-5

Abstract: Over recent years, novel gene mutations have been found in patients with AML.These mutations can be divided into two important categories, class I mutations that confer a proliferationadvantage and class II mutations that inhibit myeloid differentiation.Screening for some of these mutations is now part of the initial diagnostic work-up in newly diagnosedBesides chromosomal rearrangements and gene mutations, epigenetic regulation of genes – meaning

Keywords： acute myeloid leukemia     mutations     risk stratification    

HTML PDF Collect

Damage identification in connections of moment frames using time domain responses and an optimization

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 4,   Pages 851-866 doi: 10.1007/s11709-021-0739-3

Abstract: In this study, an optimization-based method for joint damage identification of moment frames using theThen, the problem of joint damage identification is converted to a standard optimization problem.Then, a comparison between the proposed method and the existing damage identification method is provided

Keywords： damage identification     beam-to-column connection     time-domain response     optimization    

HTML PDF Collect

Title Author Date Type Operation

Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Journal Article

Mechanical design, modeling, and identification for a novel antagonistic variable stiffness dexterous

Journal Article

Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular

Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,

Journal Article

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Journal Article

Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Journal Article

Characteristics of compensatory mutations in the

Shengfen Wang, Yang Zhou, Bing Zhao, Xichao Ou, Hui Xia, Yang Zheng, Yuanyuan Song, Qian Cheng, Xinyang Wang, Yanlin Zhao

Journal Article

122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article

Conceptual design and kinematic analysis of a novel parallel robot for high-speed pick-and-place operations

Qizhi MENG, Fugui XIE, Xin-Jun LIU

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

Variational mode decomposition based modal parameter identification in civil engineering

Mingjie ZHANG, Fuyou XU

Journal Article

Genomic Mutations within the Host Microbiome: Adaptive Evolution or Purifying Selection

Jiachao Zhang,Rob Knight,

Journal Article

Non-convex sparse optimization-based impact force identification with limited vibration measurements

Journal Article

The research on structural damage identification using rough set and integrated neural network

Juelong LI, Hairui LI, Jianchun XING, Qiliang YANG

Journal Article

Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Journal Article

Damage identification in connections of moment frames using time domain responses and an optimization

Journal Article